Born in Genoa in 1589 and member of the Spinola family, the figure of Alessandro Spinola was chosen at the age of 23 to pay homage from the Republic of Genoa to the ambassador of the Spanish court and also to assist him in his Genoese stay.

Around 1614 he assumed his first state office as protector of poor prisoners and, subsequently, in the magistrate of the Extraordinary.

[1] He was elected doge on 9 October 1654: the sixty-seventh in biennial succession and the one hundred and twelfth in republican history.

[2] Among the events of his dogato is recorded in the annals the fight against piracy along the Ligurian coast, the continuation of the work of the Albergo dei Poveri in Genoa and a new plague epidemic that decimated the Genoese population and the nearby villages.

[2] He died in Genoa during 1665 and was buried inside the church of San Francesco di Castelletto.