His compositions include the monumental Missa sopra Ecco sì beato giorno for up to 60 voices, rediscovered in 2005 after being lost for 400 years.
He had some connection to the Bavarian court in Munich, and may have gone there on more than one occasion (possibly for the performance of his 40-voice motet Ecce beatam lucem which he wrote for a royal marriage there).
In 1586 Striggio moved to Mantua where he remained for the rest of his life, although he retained a close association with the Medici, composing music for them at least as late as 1589.
Twenty-eight madrigals from Striggio's Late Period, were transcribed from microfilm for a graduate seminar at the University of California at Berkeley (under the tutelage of Dr. Anthony Newcomb in 1974).
A work on a yet larger scale, and long reputed to be lost, is Striggio's mass composed in 40 parts, and which included a 60-voice setting of the final Agnus Dei.
The work was recently unearthed by Berkeley musicologist Davitt Moroney and identified as a parody mass, Missa sopra Ecco sì beato giorno, and received its first modern performance at the Royal Albert Hall during the London Proms on 17 July 2007 by the BBC Singers and The Tallis Scholars conducted by Moroney.
This work was most likely composed in 1565/6, and carried by Striggio on a journey across Europe in late winter and spring 1567, for performances at Mantua, Munich and Paris.