A member of the Spani family, which ruled Drivast, in the mid-15th century he settled in Venice and served as a diplomat of the republic in the Ottoman Empire.
This was disputed by Franz Babinger on the account that Đurađ had only two daughters, Mara and Katarina.
Muzaka informs us that Span had six children: Marco, Biasio, Lucia, Demetria, Angela and Andriana.
Karl Hopf also presented a seventh child named Alessandro.
Span played an important role as an intermediary during the peace negotiations between Venice and the Ottoman Empire represented by Mahmud Pasha in the late 1460s.