In 1872, Dr. George Leslie Mackay, a missionary from the Presbyterian Church in Canada, designed and supervised the construction of the original school building.

[3] The Northern Synod of the Presbyterian Church in Taiwan was the founder of the later university, which the group planned in 1959 to establish at the location of Oxford College.

In August 1965, the Ministry of Education gave approval for the Tamsui Institute of Industrial & Business Administration.

The Matou branch began accepting students, with an emphasis on two-year technical education, in February 1997.

They are organized into five colleges including Humanities, Finance and Economics, Management, "Tourism, Leisure, and Sports", and Information Sciences and Business Intelligence.