Following his high school career, Boone was invited to play in the U.S. Army All-American Bowl in December, and the following month he enrolled at Ohio State.

In his four years with the Buckeyes, Ohio State compiled a 41–8 record and captured four Big Ten Conference titles and played in four BCS Bowl appearances.

In his third-year as a starter at the left tackle position, Boone was named a second-team All-Big Ten by the media, coaches and Rivals.

As a senior in 2008, Boone was named first-team All-Big Ten and second-team Walter Camp Football Foundation All-America.

After being signed by the San Francisco 49ers as an undrafted free agent following the 2009 NFL Draft, Boone was released on the final day of roster cuts.

In the offseason following his rookie season, Boone returned home to Lakewood, Ohio, where he began working out with former NFL Pro Bowl center LeCharles Bentley.

In Week 17, Boone made his NFL debut against the Arizona Cardinals on January 2, 2011, entering the game at left tackle in the second half.

In Week 15, Boone and the offensive line prevented quarterback Alex Smith from getting sacked in a 20–3 win on Monday Night Football (MNF) against the Pittsburgh Steelers.

In Week 1, Boone made his first career NFL start against the Green Bay Packers, lining up at right guard and helping running back Frank Gore rush for 112 yards.

It also marked the first time in 49ers history since November 19, 1961 against Chicago that San Francisco posted a 300-yard passer (quarterback Alex Smith 303 yds.

Boone and the 49ers offensive line did not allow a sack on 25 pass attempts by rookie quarterback Colin Kaepernick in the victory against the New Orleans Saints on November 25.

Against the Packers, San Francisco amassed 579 total yards of offense (323 rushing and 256 passing), setting a new single-game postseason franchise record.

[6] Before the 2013 season, Jeff Deeney of Pro Football Focus (PFF) named Boone the 49ers' secret superstar for his performance in 2012.

The offensive line did not allow a sack on 17 total attempts by quarterbacks Colin Kaepernick and Colt McCoy in the win over the Jacksonville Jaguars in Week 8.

In Week 16 against the Atlanta Falcons, he provided great running lanes for the offense to gain 199 rushing yards on 30 attempts.

In Week 16, he contributed as part of an offensive line that led the way for the team to rush for a franchise record 355 yards against the San Diego Chargers.

In Week 1, Boone was part of an offensive line group that helped the team rush for 230 total yards against the Minnesota Vikings, the most in franchise history during a season opening game.

The offensive line helped pave the way for second-year running back Carlos Hyde as he rushed for an NFL Week 1-high of 168 yards and 2 touchdowns.

In Week 9, Boone and the 49ers offensive line did not allow a sack on 25 attempts by quarterback Blaine Gabbert against the Atlanta Falcons, and he helped pave the way for 133 yards rushing.

[21] Boone began coaching various pee wee football teams as well as running a yearly Offensive Line gym.

Boone was convicted of driving under the influence in 2006[22] and was arrested on February 1, 2009, after allegedly jumping on car hoods, yanking on a tow truck cable and trying to break a window.