He won an NBA championship with the Los Angeles Lakers in 2020 as well as earning selections to two consecutive all-defensive teams as a member of the Chicago Bulls in 2023 and 2024.

Caruso attended A&M Consolidated High School in his native College Station, Texas, where he played basketball under head coaches Rusty Segler and Rick German.

[6] As a senior he led the Aggies to the Sweet 16 of the NCAA Tournament; he also earned SEC All-Defensive Team and second-team All-SEC honors.

[12] Caruso signed another two-way contract with the Los Angeles Lakers after a successful showing in the 2018 NBA Summer League.

[14] On April 7, 2019, with the Lakers missing James for the remaining six games, Caruso scored 18 points with a career-high 11 assists in a 113–109 home win over the Utah Jazz.

[22] On October 27, 2023, Caruso put up 13 points, 13 rebounds, two assists, two steals, and one block alongside a game-winning three-pointer in a 104–103 overtime win over the Toronto Raptors.

[24] The move reunited Caruso with Mark Daigneault who coached him during his tenure with the Oklahoma City Blue.

[5] On June 22, 2021, Caruso was arrested at Easterwood Airport in College Station, Texas, for residual marijuana left on a grinder.