In 1998, he led the team at tight end and middle linebacker to a 10–4 record, and a berth in the Division VII CIF Southern Section championship game.
Holmes played for the Miami Dolphins in 2005 and signed as a free agent with the St. Louis Rams for 2006.
Holmes' younger sister is married to Pittsburgh Steelers safety Troy Polamalu.
His younger brother Khaled was an offensive lineman at USC, and currently plays for the Indianapolis Colts.
Known for repeatedly torching unsuspecting defenders, he continues playing in some of Southern California's premier basketball leagues.