He is best known for co-writing the scripts to Transformers (2007), Transformers: Revenge of the Fallen (2009), Star Trek (2009), Star Trek Into Darkness (2013), and The Amazing Spider-Man 2 (2014) with his writing and producing partner Roberto Orci, and directing and co-writing The Mummy (2017).

[5] Kurtzman first teamed with Orci on the syndicated series Hercules: The Legendary Journeys, for the television unit of Pacific Renaissance Pictures, then operating out of Universal International.

In 2011, Forbes magazine described Orci and Kurtzman as "Hollywood's Secret Weapons" as, over the course of the previous six years, their films had grossed a combined total of over $3 billion at the box office.

[6] Kurtzman has frequently worked with a tight-knit group of film professionals which include J. J. Abrams, Damon Lindelof, Adam Horowitz, Roberto Orci, Edward Kitsis, Andre Nemec, Josh Appelbaum, Jeff Pinkner, and Bryan Burk.

[9] In August 2021, Kurtzman and his production company Secret Hideout extended their overall deal with CBS Studios through 2026.