He is the recipient of multiple Tony and Grammy Awards for his work on shows such as In the Heights (2008), Hamilton (2016), and Dear Evan Hansen (2017).

Lacamoire was born in Los Angeles, California and began to play piano at age four.

In 2007, Lacamoire received a Drama Desk Award nomination for Outstanding Orchestrations for the Off-Broadway production of Lin-Manuel Miranda's In the Heights.

Lacamoire was the music director, orchestrator, and conductor for the Broadway production of Hamilton at the Richard Rodgers Theatre, continuing in the roles he held during the show's Off-Broadway production at The Public Theater, as well as the Co-Arranger (along with Lin-Manuel Miranda) of the show's score.

The adaptation features the classic opera score using all-new Cuban musical arrangements.

For that Cuban-American production, Lacamoire related it entailed channeling music that's “in my blood.”[1] The show began a European tour in July 2018.

In late 2017, Lacamoire reunited with Lin-Manuel Miranda on his song "Almost Like Praying" to benefit Hurricane Maria relief and recovery operations in Puerto Rico.

The song featured the 5 Elizas who took on the role after Phillipa Soo left the show in July 2016.