In 2006, Megos began training in the mountainous region of his native Bavaria, known as Franconian Switzerland, and later at the German Alpine Club's national climbing center in Erlangen-Nuremberg.

[4] In 2017, he was the runner-up in bouldering at the European Championship and won his first World Cup in the lead climbing discipline in Briançon, France, on 21 July 2018.

[5] In 2017, he won the silver medal for bouldering at both the European Championships in Munich and the IFSC Lead World Cup in Kranj, Slovenia.

By reaching the finals of the combined event at the World Championships, he secured a qualifying spot for Tokyo's 2020 Summer Olympics.

[10] He currently holds the high point of Black Diamond's The Project, which is widely considered one of the world's hardest indoor routes.

[13] In addition, he is the only person to complete an asccent of Biography also known as Realization 9a+ (5.15a) in Ceüse, France in a single day of effort.

On 9 May 2018, he secured the first ascent of the route Perfecto Mundo in Margalef, Spain, a line bolted by Chris Sharma.

In August 2020, Megos completed his long-term project Bibliographie in Céüse, grading it 9c (5.15d), after working on it for 60 days.