Niño studied medicine briefly at the University of Manila before leaving in 1959[4] to pursue his childhood goal of becoming a comics artist.

[6] With writer-editor Robert Kanigher, Niño created DC's 19th-century Caribbean-pirate protagonist Captain Fear in Adventure Comics #425 (Dec.

[7] Niño and writer Jack Oleck created the science-fiction feature "Space Voyagers" in Rima, the Jungle Girl #1 (May 1974).

[6] Niño instead found his niche in the mature-audience horror and science-fiction/fantasy fare of Warren Publishing's black-and-white comics magazines Creepy, Eerie, 1984, and Vampirella, and HM Communications' pioneering Heavy Metal, a color comics magazine that blended imported European art-comics with new American work.

[11] Later 1980s work includes issues of New Comics Group's Asylum, World of Young Master Special, and Demon Blade, and Fantagor Press' Den.

Leaving comics again the following year, Niño returned in 1999 to write and draw a story each in Quantum Cat Entertainment's Frank Frazetta Fantasy Illustrated #7-8 (July & Sept.

[6] After another hiatus from comics, during which time he worked on designs for the Walt Disney Pictures animated feature Atlantis: The Lost Empire (2001),[12] Niño returned to draw Bliss on Tap Publishing's four-issue series God the Dyslexic Dog (July 2004).

In 2008, Niño drew the three-issue miniseries Dead Ahead, by writers Mel Smith and Clark Castillo for Image Comics.

[13] Though now officially retired, Niño continues to produce artwork for commissions, attend fan conventions and teaches art classes every year back in the Philippines.