Hacke has released two full-length solo albums, and has also collaborated with many other artists, such as Robert Rutman, The Tiger Lillies, Danielle de Picciotto, FM Einheit, Crime & the City Solution, Phew, Gianna Nannini, Gry, Miranda Sex Garden, Terranova, Sprung aus den Wolken, Wovenhand, David Yow, Mona Mur, Die Ichs, Schlaflose Naechte, Fred Alpi and others.

In 2003 Alexander Hacke and his longtime partner Danielle de Picciotto (married since 2006) organized the monthly event "BadaBing" in the famous Berlin 70s Club "Big Eden", presenting new and unusual bands and in this way initiating a new wave of Berlin-oriented "Futur-electroclash" music all over Europe.

In 2005 Hacke and de Picciotto conceived and directed "The Mountains of Madness", an audio/visual live show based on stories by H. P. Lovecraft, inviting the English Trio The Tiger Lillies to participate and perform in the successful production throughout Europe.

In the 2000s Hacke created the album Sanctuary (released in 2005), travelling with a mobile recorder in Europe and North America and collaborating with numerous artists, such as J.G.Thirlwell (Foetus), Caspar Brötzmann, Larry Mullins (also known as Toby Dammit), Vinnie Signorelli (Unsane), Michael Evans (KBZ 200), Sugarpie Jones (Celebrity Skin), Bob Rutman (Steel Cello Ensemble), Nils Wohlrabe (The Leather Nun), Gianna Nannini, Andrew Chudy (alias N.U.

[2][3] Hacke's first noteworthy girlfriend was Christiane F., who became famous with the internationally acclaimed movie and book Wir Kinder vom Bahnhof Zoo, a biography of her heroin addiction.

In 2006, Hacke married his longtime partner Danielle de Picciotto, an American Berlin-based multimedia artist who is known for having founded the Berlin Love Parade together with Dr Motte and for singing in the band Space Cowboys.