Khokhlachev played in the 2006 Quebec International Pee-Wee Hockey Tournament with the Moscow Selects youth team.

[6] On April 13, 2014, Khokhlachev made his NHL debut[7] skating 15:14 with the Boston Bruins in a 3–2 loss to the New Jersey Devils.

[10] It was later confirmed that on July 1, 2016, Khokhlachev signed a two-year deal with SKA Saint Petersburg, with his NHL rights still to be held by the Bruins.

On August 18, 2017, Khokhlachev was traded approaching his final year of contract by SKA in a return to former club, Spartak Moscow, in exchange for Yaroslav Dyblenko.

[13] Prior to the 2022–23 season, Khokhlachev was traded by Spartak to Amur Khabarovsk in exchange for a prospect and financial compensation on 30 August 2023.