Alexander Hepburne Macklin OBE MC TD (1 September 1889 – 21 March 1967) was a Scottish physician who served as one of the two surgeons on Sir Ernest Shackleton's Imperial Trans-Antarctic Expedition of 1914–1917.

After working for a short amount of time as a deckhand, he continued his education at the Victoria University of Manchester, where he qualified as a surgeon/doctor.

After arriving at Elephant Island, Shackleton and five men took one of the boats, the James Caird, and set out to fetch help from South Georgia.

Macklin and McIlroy, the other surgeon, were left behind as Shackleton knew the skills would be required more on the island than on the boat: Rickinson had a heart condition, Hudson was suffering a nervous breakdown.

On his return to Britain, Macklin gained a commission as a temporary lieutenant in the Royal Army Medical Corps (RAMC), with effect from 22 November 1916.

After the war, Macklin continued to serve with the RAMC, seeing service with the Allied Expeditionary Force in Northern Russia along with his old Boss, Shackleton.

[6] Together with former Endurance crew members Worsley, Hussey, Wild, McIlroy, Kerr, McLeod and Charles Green, Shackleton invited Macklin to join him for the Shackleton–Rowett Expedition in 1922 on board the Quest.

At the start of World War II, he returned to active service as a major in the Medical Corps, serving in East Africa and rising to lieutenant-colonel.