That night, Radulov tied the Remparts team's record with Eric Chouinard for most points in a single game, with seven.

Later, on 19 March 2006, in a game against the 2005 Memorial Cup second-place finishing Rimouski Océanic, for whom his teammates Cédrick Desjardins and Michal Sersen played for in 2004–05, Radulov wrote history in the Québec Colisée by scoring an unprecedented 7 goals and 4 assists for 11 points, breaking both records for most goals and points in a single game for the Remparts, in a lopsided 16–3 victory.

Radulov owns the Remparts record for the most consecutive point streak games with 50, passing the 28-game mark established by Eric Chouinard in the 1999–2000 season.

Radulov delivered an incredible performance in the Remparts' 2006 Memorial Cup championship game victory over the Moncton Wildcats.

He registered nine points (five goals and four assists) in four games and won the Stafford Smythe Memorial Trophy as the tournament MVP.

During Radulov's 2005–06 season in the QMJHL, he signed a three-year, entry-level professional contract with the Nashville Predators on 9 January 2006.

On 21 October 2006, Radulov made his NHL debut with the Predators against the Vancouver Canucks, logging seven minutes and one minor penalty.

Bernier was sent into the boards head first and lay motionless on the ice for three minutes, before being helped off by teammates Joe Thornton and Marcel Goc.

Radulov had previously notified the Predators organization of his desire to play in Russia, stating that he was being offered better conditions.

[5] Immediately after the announcement, the Predators, NHL and the International Ice Hockey Federation (IIHF) all released statements emphasizing that Radulov's contract obligated him to play for the Predators through the 2008–09 season and that signing with a team in Russia was a direct violation of an agreement made the previous day between the NHL and all international hockey leagues to respect players' existing contracts.

[8] While the contract remained disputed, the IIHF suspended Radulov from international play on 18 July as investigations continued,[9] although the suspension was soon lifted.

The team would win a second straight Continental Cup, but in the playoffs, they would lose in the Eastern Conference Final to eventual champions Ak Bars Kazan in six games.

Salavat Yulaev Ufa would finish second in the league, with division rival Avangard Omsk winning the Continental Cup.

Radulov won his second Golden Stick Award as KHL regular season MVP and made the All-Star team again.

At the conclusion of the previous championship winning season, the contract of head coach Vyacheslav Bykov was expiring.

At the time, Bykov also served as the head coach of the Russian national team, having held the post for the previous five years.

Unfortunately, a poor showing for Russia at the 2011 IIHF World Championship, where the team finished without a medal for the first time under his tenure, prompted Salavat not to renew his contract with the club.

On 1 May 2012, Radulov and Predators teammate Andrei Kostitsyn were spotted at a Scottsdale, Arizona, bar at 5:00 AM the night before Game 2 of their second round playoff series against the Phoenix Coyotes, thus breaking team curfew.

On 2 July 2012, Radulov signed a four-year contract with CSKA Moscow of the KHL worth an average annual value of $9.2 million.

In the playoffs, CSKA reached the Conference Final of the Gagarin Cup, losing in Game 7 to the eventual champions SKA Saint Petersburg.

However, CSKA would then fall short of their ultimate goal and lose Game 7 of the Gagarin Cup Final to champions Metallurg Magnitogorsk.

On 1 July 2016, Radulov returned to the NHL as a free agent, signing a one-year, $5.75 million contract with the Montreal Canadiens.

At the 2014 Winter Olympics in Sochi, Radulov led Russia in goals (three) and points (six) in five games, though the team lost in the quarter-finals to Finland, ultimately finishing in fifth place.