In March 2013, he moved to the Ministry of Economic Development, to the post of assistant head of the department, Andrey Belousov.

From September to December 2013, he became the Director of the Department of the activities of the head of the Ministry of Economic Development.

On November 19, 2014, Aleksandr Tsybulsky was appointed Deputy Minister of Economic Development for Alexey Ulyukaev.

But after the arrest of Ulyukayev and his resignation in connection with the loss of the president's confidence, on November 30, 2016, he was appointed Deputy Head of the Ministry of Economic Development, under Maxim Oreshkin.

On September 28, 2017, he was appointed acting governor of the Nenets Autonomous Okrug, when Igor Koshin decided to leave the post.