[4] Schepisi made her acting debut as a baby, in the role of Baby Hersey in the 1978 drama film The Chant of Jimmie Blacksmith, which her father scripted and directed.

Schepisi has performed on stage, including the Melbourne Theatre Company production A Doll's House.

Schepisi has appeared in a number of Australian films and television shows.

Her TV acting credits include The Secret Life of Us (2001), MDA (2002), Underbelly (2008), and Devil's Dust (2012).

On the other hand, she starred in films The Boys Are Back (2009), Matching Jack (2010).