Lacazette was a key contributor in France's victory in the 2010 UEFA European Under-19 Championship, where he scored the match-winning goal in the final against Spain.

[10] As a youth player, Lacazette played in the club's under-18 team that finished in third place in the Championnat National des moins de 18 ans during the 2007–08 season.

[14] Lacazette's successful campaign in the 2010 UEFA European Under-19 Championship saw the player draw interest from Italian club Roma.

Lacazette scored Lyon's only goal in the 2014 Coupe de la Ligue final against Paris Saint-Germain; however his side lost 2–1.

[26] Amid transfer speculation from a number of Premier League clubs such as Arsenal following his break-out season, on 8 August 2015, Lacazette signed a new deal, extending his contract with Lyon until 2019.

[28] On 9 January 2016, he scored the first goal at the newly opened Parc Olympique Lyonnais, in a 4–1 win over Troyes in a Ligue 1 match.

[30] On 22 November, he scored the only goal by slotting home Rafael's rolled cross from close range in the 72nd minute of the 2016–17 UEFA Champions League group stage Group H matchday 5 1–0 away win against Dinamo Zagreb to keep alive Lyon's hopes of progressing to the knockout phase of the 2016–17 UEFA Champions League.

[31] In early February 2017, Lacazette reportedly revealed to television show Canal Football Club his intention to leave Olympique Lyonnais in the summer of 2017.

[32] In May 2017, it was reported that a verbal arrangement had been reached for Lacazette to join Atlético Madrid in the summer of 2017, but that fell through on 1 June 2017, after the Court of Arbitration for Sport upheld Atlético's ban on registering players for two transfer windows (1 January – 2 February 2017 and 1 June – 31 August 2017) that was imposed in July 2016 by FIFA on the club for breaching FIFA rules over the signing of minors.

Despite hitting the post midway through the first half, Arsenal eventually won 4–1 on penalties after the game ended 1–1 at full time.

[40] On 11 August, Lacazette made his Premier League debut against Leicester City and scored after 94 seconds to give Arsenal a 1–0 lead in an eventual 4–3 win.

[42] With his goals against West Brom, Lacazette became the first Arsenal player to score in his first three home league appearances for the club since Brian Marwood in September 1988.

[44] Lacazette claimed his sixth goal of the season in Arsenal's 3–1 away defeat to Manchester City after latching onto an Aaron Ramsey pass, despite not starting the game.

[46][47] Following a protracted period on the sidelines through injury, Lacazette returned to the Arsenal squad in the 3–0 home win over Stoke City in March, where he replaced Danny Welbeck in the 61st minute and scored the Gunners' third goal of the game, after new signing and designated penalty-taker Pierre-Emerick Aubameyang, allowed Lacazette to take the penalty.

[48] Lacazette would then score twice on his Europa League debut for Arsenal, in a 4–1 win against CSKA Moscow, marking his first goal in European competition for the club.

[49] Lacazette then registered his third goal in European football for Arsenal, by scoring in the Europa League semi-final 1–1 draw with Atlético Madrid.

[52][53][54] Lacazette made his first start under Emery in Arsenal's 3–2 away win over Cardiff City on 2 September, where he registered an assist and scored his first goal of the season.

[60] He scored three goals in three league starts in September and was voted as the runner up of the Player of the Month on Arsenal official website.

[68] On 10 March 2023, Lacazette scored a late-match brace in a 3–3 draw against Lille, becoming the joint second-highest goalscorer in Lyon's history, tied with Bernard Lacombe at 149 goals.

[77] He featured in ten of the eleven matches the team contested scoring one goal, which came against Denmark in the Tournoi de Limoges.

[78] For under-19 duty, Lacazette was again called upon by coach Francis Smerecki, making his first appearance for the team in a 4–2 defeat against Netherlands on 9 November 2009.

[4] He made his international debut on 5 June, as a 58th-minute substitute for Olivier Giroud in a 0–1 friendly defeat against Uruguay at the Estadio Centenario in Montevideo.

[87] Lacazette scored his first international goal on 29 March 2015, opening a 2–0 friendly win over Denmark at the Stade Geoffroy-Guichard in Saint-Étienne.

[93] He had played as one of the permitted overage players in the French under-23 team (who represent France in the Olympics), during the lead-up to the tournament against the Dominican Republic in an international frendly.