Negrão's career started in karting in 1998, where he continued to race until he joined the Piquet team in Formula Three Sudamericana for the 2003 season.

He ended the 2004 season as the champion, and also got a taste of British Formula Three that year, in the form of two races for the Carlin Motorsport team.

He scored only four points, but improved to thirteen in 2006, as Piquet unsuccessfully fought with Lewis Hamilton for the championship.

However, Negrão had a very disappointing season, scoring fewer points than the previous year and being outscored by his rookie teammate Roldán Rodríguez.

Xander was married to Brazilian actress Marina Ruy Barbosa between October 2017 and January 2021, when the couple filed for divorce.