Her mother Valerie Popova was an internationally acclaimed soprano who sung regularly at La Scala in Milan from 1983 to 1986.
The soprano's debut outside Bulgaria took place in Bilbao, where she sang the title role in Lucia di Lammermoor.
Since 1989 she has sung in many of the most prestigious opera houses around the world, including those in Vienna, Paris, Berlin, New York (at the New York City Opera), Rome, Brussels, Washington, Hamburg, Moscow, Turin, Naples, Santa Fe, Bregenz, Monte Carlo, and Tel Aviv.
During the 1997–2001 operatic seasons Pendatchanska sang the role of Elisabetta in Roberto Devereux (Turin and Naples), Adina in Adina (Pesaro), Suor Angelica in Suor Angelica (Lucca), Luisa in Luisa Miller (Naples and Berlin), and in Ermione (Santa Fe and New York).
Her concert repertoire includes the Requiem by Verdi, Rossini's Stabat Mater and Petite messe solennelle, and Le Roi David by Honegger.