Born in Longa, Maniema province, Thambwe Mwamba is a practicing lawyer in the Democratic Republic of Congo and possibly one of the longest serving public servants of the country from the time he was first appointed Minister of Public Works in 1985 serving in the government of Mobutu Sese Seko.

[3] A Belgian magistrate investigated Thambwe Mwamba for money laundering, over payments he allegedly received to finance the war from international trafficking of coltan.

In late August 2009, shots were fired at his house as a threat against testifying in the trial at the International Criminal Court of Bemba.

[3] 27 July 2019 Alexis Thambwe Mwamba was elected President of the Senate.

[5] On 5 February 2021, he resigned from this position, thereby avoiding an anticipated removal process.