Paul Fusco, the creator and puppeteer of ALF in the live-action series, was the only cast member to reprise his role; none of the human characters from the prime time ALF appeared in the animated series, due to its nature as a prequel and its setting being on Melmac rather than Earth.

[4] The format of the series is that of a situational comedy, or sitcom, with much of the humor deriving from the characters partaking in ordinary activities, but in an alien environment.

Gordon Shumway is a teenager who lives in suburban East Velcro on the planet Melmac with his parents Bob and Flo, his brother Curtis, his younger sister Augie, and their dog Neep.

The show also features supporting characters, such as the fortune teller Madame Pokipsi and the villainous Larson Petty and his sidekick Eggbert.

Some episodes can also be found in the special features section of the collectors edition release of the original live action series.