[4] Robert Kubica drove for the team at the Dutch and Italian Grands Prix replacing Räikkönen who withdrew from the events after testing positive for COVID-19.

[5] The chassis was designed by Jan Monchaux, Luca Furbatto, Lucia Conconi, Alessandro Cinelli and Nicolas Hennel with the car being powered by a customer Ferrari powertrain.

Alfa Romeo spent their tokens on improving the nose of the car, adopting a slimmer design to redirect air over the bargeboards.

Journalists and technical analysts Mark Hughes and Giorgio Piola described the C41 as the most-improved car over its 2020 equivalent, calling it "both more powerful and more aerodynamically competitive than its C39 predecessor" due to a combination of power unit development by Ferrari and Alfa Romeo's own improvements.

At the Abu Dhabi Grand Prix, two different messages featured on the engine cover: Räikkönen's car reads "Dear Kimi, we will leave you alone now", this is a reference to his famous quote at the 2012 Abu Dhabi Grand Prix when he wins for the first time since two years leaving the sport, while for Giovinazzi's car reads "Grazie di tutto, Antonio" ("Thanks for everything, Antonio").