Alfredo Dugès is largely remembered for his extensive studies of Mexican herpetology.
With his brother, entomologist Eugenio Dugès (1826–1895), he organized frequent field trips in order to collect specimens.
Dugès published numerous scientific papers in several fields including herpetology, botany, and entomology.
At Guanajuato, he was director of the local museum, later named the Museo Alfredo Dugès (es) in his honor.
In Mexico, he described 40 new species of reptiles and amphibians, of which nearly half are considered valid today.