[6] On 24 July 2014, Morelos started his first game for Independiente Medellín and scored his first ever senior goal, aged 18 years, 1 month and 3 days in a 2–0 win over Evigado also in the Copa Colombia.

[8] Morelos featured three more times for Independiente Medellín in the group stage of the competition scoring a further two goals, one against Leones on 21 August 2014 in a 3–0 win[9] and one seven days later against Evigado in a 1–1 draw.

[12] Six days later on 6 September 2014, Morelos scored his first Categoría Primera A goal for Independiente Medellín during injury time against Fortaleza Esporte Clube to win the match 3–2 in the 92nd minute.

[14][15] Morelos ended the 2014 season with fourteen appearances and six goals in all competitions for Independiente Medellín and received a 2014 Categoría Primera A Finalización runner-up medal.

[16] Morelos made eleven appearances in all competitions in the 2015 season, six in the Categoría Primera A and five in the Copa Colombia but failed to find the net in any of the matches.

[20][21] Morelos made an immediate impact on his debut four days later in the Finnish League Cup, coming on as a substitute in the Stadin derby against HIFK and scored in the 90th minute to make the game 3–3.

[50] HJK took up their option to sign Morelos permanently for a fee of €500.000, and he started 2017 by scoring in the first game of the season in a 3–2 victory over FC Honka on 28 January 2017 in the Finnish Cup group stage.

[66] For his excellent form and goalscoring which included ten goals in eleven appearances Morelos was awarded the Veikkausliiga Player of the month for both April 2017 and May 2017.

[16] HJK went on to win the 2017 Veikkausliiga by twenty points and the 2016–17 Finnish Cup defeating SJK 1–0 in the final on 23 September 2017 with Morelos receiving two winners medals for his contributions over the season.

[74] He made his debut for Rangers in a 1–0 home win against Progrès Niederkorn in the Europa League first qualifying round first leg ten days later, coming on in the 77th minute in place of Martyn Waghorn.

[80] However, a sign of future disciplinary issues arose when he was sent off against Aberdeen at Pittodrie Stadium in the opening league fixture for a kick out at an opponent, although the red card was rescinded on appeal.

[85] The appeal was unsuccessful, but Morelos was able to play in a Scottish Cup tie while serving a three-match League ban, and scored four goals in that match, a 5–0 win over Kilmarnock, to take his tally for the 2018–19 campaign to 27 in 39 appearances.

[87] Later that month, Morelos received a straight red card for an incident with Celtic's Scott Brown in an eventual 2–1 loss for Rangers in the Old Firm derby; it was his fifth sending off of the season, although one of them was rescinded.

He started the season in goalscoring form, netting five in his first seven games including braces against St Mirren in the Scottish Premiership[106] and Lincoln Red Imps during Europa League qualifying.

[109] He continued his rich vein of form in the group stage of the Europa League by scoring against both Polish side Lech Poznań on 29 October 2020,[110] and Portuguese giants Benfica on 5 November.

[113] His performance proved controversial due to an off the ball incident where he appeared to stamp on Hibernian player Ryan Porteous, and was subsequently given a three match ban.

[116] On 21 March, he scored his first goal in the Old Firm derby during a 1–1 draw away at Celtic Park; later reports emerged that he was the subject of racial abuse over social media perpetrated by alleged opposition fans.

[131] On 25 November 2021, in their first match under new manager Giovanni van Bronckhorst, Rangers defeated Sparta Prague 2–0 in the Europa League group stage at Ibrox; Morelos, who had not scored in the previous four group matches, got both goals to ensure their head-to-head record was superior to their opponents (who had won 1–0 in the Czech Republic)[132] and secured qualification for the knockout stages of the competition for the third season in a row.

[145] Morelos season was cut short with his final appearance being in a 2–1 away win over Dundee on 20 March[146] after he sustained an injury whilst on International duty which required him to undergo surgery on his thigh.

[148][149] Without Morelos Rangers reached the Europa League Final which they narrowly lost to Eintracht Frankfurt 5–4 on penalties at the Ramón Sánchez Pizjuán Stadium in Seville after the two sides could not be separated after 120 minutes.

[150] Although Morelos never took part in the final he received a runners-up medal for his earlier contributions in the European campaign which included vital goals for Rangers to be able progress to that stage in the tournament.

[152] On 20 August 2022 during a 2–2 draw with Hibs, Morelos received his eighth red card for Rangers after he swung his arm in the face of Marijan Čabraja when both players went to head the ball.

The commentators and pundits felt the red card was harsh and it meant that Rangers had to finish the game with nine men as John Lundstram had just been sent off nine minutes prior to the incident.

[153] Following this manager Giovanni van Bronckhorst took the decision to drop Morelos from the squad to face PSV Eindhoven in the Champions League Play-off round (which Rangers went on to win 3–2 on aggregate and qualify for the Champions League group stage for the first time in 12 years) citing concerns over his attitude and fitness levels but stressed that Morelos still had a future at the club if he could prove his commitment.

[154] Morelos made his first start for Rangers in six months and his first ever Champions League group stage appearance on 14 September 2022 in a 3–0 defeat against Napoli at Ibrox.

[163] Despite being regularly used in the 2024 Campeonato Paulista as Peixe finished runners-up, Morelos was separated from the first team squad in April, with president Marcelo Teixeira stating that the decision was due to "technical reasons".

It is not a simple operation with Santos, but we hope to be able to achieve it.”[177] On 13 December 2024, Morelos scored in the Copa Colombia final first leg during a 3–1 victory over rivals América de Cali to take his tally to four goals in six cup games, two days later he played in the second leg as the teams drew 0–0 with Atletico winning the Copa Colombia final 3–1 on aggregate and handing Morelos his first ever trophy in his homeland.

[179] On 29 January 2025, Morelos completed another loan move back to Atlético Nacional until the end of the 2025 season with the Colombian club having the option to buy for £2.5 million.

[193][194] He was not named in the 40-man preliminary squad announced on 16 May for the 2019 Copa América, with several media outlets speculating his poor on-field discipline at club level in Scotland contributed to his omission.

[211] In October 2024, Morelos was involved in a traffic accident, after hitting a motorcyclist with his SUV; he also failed a breathalyzer test, and was subsequently arrested for drink-driving.