Completed as the Tripoli Cathedral in the 1920s during the Italian Libya colonial era, the building was repurposed as the mosque in c. 1970.

[1] In July 1970, after the rise to power of Muammar Gaddafi, the Revolutionary Council ordered the confiscation of all Italian and church property.

In September of the same year, the Vicar Apostolic of Benghazi was expelled and the cathedral was closed.

[3] Due to the controversial nature of this information, and due to intentional Historical negationism by the Gaddafi regime and its unreliable sources, the official conversion may have begun later with certain parts of the cathedral changed, and then fully, and visibly completed on the exterior circa late 1990–2000.

The cathedral was renamed "as Jamal Abdul Nasser Mosque" and is currently being used as a place of worship.