Two years later, Ali played a significant role in the suppression of the Celali rebellions in Ottoman Anatolia as well as the subdual of Janbirdi al-Ghazali in Syria in 1521.

Ali's death allowed the intended Ottoman seizure of the Dulkadirid realm and marked the end of his dynasty's rule.

The Beylik of Dulkadir was founded by Zayn al-Din Qaraja (r. 1337–53), a local Turkmen lord, as a client state of the Mamluk Sultanate, in southern Anatolia and northern Syria.

After his cousin Pirbende presented their heads to Selim in Sakallu, near Eleşkird, on 18 August 1514, Ali received a reward of 3 thousand florins and the sword of Hersekzade Ahmed Pasha.

[2] In November, Selim appointed Ali as the sanjak-bey of Kayseri, a more valued position than that in Chirmen,[3] on the border with the Dulkadirids in preparation to eliminate Bozkurt.

As ordered by Selim, Ali occupied the Dulkadirid-controlled Sanjak of Bozok in the winter and beheaded Bozkurt's son, Suleiman.

Much of the Dulkadirid troops deserted Bozkurt's four sons and brother Abdurrazaq, and fled to the mountains when they realized their leader was dead.

Ali was installed as the new ruler of Dulkadir, contrary to Qansuh's request to leave a portion of the realm to Bozkurt's offspring.

He sent a two thousand-strong support force to Bıyıklı Mehmed Pasha, who set out to Diyarbekir to break the siege headed by Qara Khan, the Safavid-appointed governor who was not allowed to govern by the city's locals.

In April 1516, Ali's forces participated in the Battle of Kochhisar, where Qara Khan died, and Ottoman rule was restored.

[7] Qansuh arrived in Aleppo on 11 July in preparation to attack the Dulkadirids as he expected Selim to be busy fighting the Safavids in the east.

When Qansuh learned of the Ottoman army's arrival in Syria, he unilaterally recognized Abd al-Razzaq as the ruler of Dulkadir and dispatched him north with a five thousand-strong force under his command.

Abd al-Razzaq and his nephew Shahruh's son, Malik Arslan, were located on the opposite side, or the left wing, of the Mamluk army.

On 13 April, Ali hanged the Mamluk Sultan Tuman bay II (r. 1516–17) at Bab Zuweila in retribution for his father's earlier execution at the same spot.

[10] Jalal (or Celal), dubbed as Shah Veli, was a Turkmen who owned timar (land grant) near Turhal and initiated a major rebellion in 1519 gathering numerous Qizilbash, including relatives of Ali.

In the region of Bozok, Jalal sacked the home of Ali's son, Uways, and defeated Shadi Pasha, the local beylerbey, in Zile, where the latter was preparing to form a resistance against the rebels.

On 24 April 1519, Ali participated in a battle lasting from dawn to dusk that killed much of the Qizilbash forces and captured their families.

Ali beheaded Jalal and sent his head to Selim, which prompted jealousy among the Ottoman governors, especially the Rumelian beylerbey Ferhad Pasha.

[11] Shortly after Selim's death in 1520, Janbirdi al-Ghazali, originally the beylerbey of Damascus, revolted taking advantage of the change in power.

Ferhad Pasha and Ali were assigned to deal with Ghazali when the latter laid siege to Aleppo with a twenty thousand-strong force.

[14] Ali's sons included Saru Arslan, Uways, Divaneh Veled,[1] Pir Ahmed, Iskender, and Hudabende (born 1515).