Alice was the maternal grandmother of Blanche of Lancaster, and thus great-grandmother of King Henry IV of England.
Alice was John Comyn's heiress to the title of Countess of Buchan, although the earldom had been forfeited to the crown prior to her uncle's death in England to where he had gone as a fugitive.
[citation needed] The marriage produced many children: In April 1313, Isabella MacDuff, the widow of Alice's uncle John Comyn, was placed into the custody of the Beaumonts, following her release from her harsh imprisonment.
It was Henry's relentless pursuit of Alice's inherited earldom of Buchan which was one of the factors that lead to the Second War of Scottish Independence between the Comyns and their ancient rivals, the Bruces.
Alice Comyn appears as a character in Barbara Erskine's novel Kingdom of Shadows (1988), which is based upon the life of Isabella MacDuff.