In addition to Alice, the district also serves the communities of Alice Acres, Amargosa, Coyote Acres, Owl Ranch, Rancho Alegre, and portions of Loma Linda East and Ben Bolt.

[1] In 2011, the school district was rated "academically acceptable" by the Texas Education Agency.

As part of a bond program approved by voters in May 2019, AISD closed Memorial Intermediate, Hillcrest Elementary, and Salazar Elementary, and made additions and renovations at the 6 remaining schools.

[10] Alice High School participates in the boys sports of baseball, basketball, football, soccer, and power lifting.

[5] The school participates in the girls sports of basketball, soccer, softball, power lifting and volleyball.