It stars Jasika Nicole as Keisha, who broadcasts on a radio signal her experiences on her road trip across America to locate her missing wife, Alice, which leads to her uncovering several mysteries and conspiracies of a supernatural nature.

[6][7] She was pitched Alice Isn't Dead during a conversation with Fink before one of the Night Vale live shows and signed on immediately, receiving scripts a few months later.

[4] The first season was partially funded through sponsored advertising by Audible Inc., Squarespace, Casper Sleep, and Blue Apron[2] – a practice that would continue with other series under the Night Vale Presents banner such as Within the Wires and The Orbiting Human Circus (of the Air).

Roberta Colindrez, who appeared in the original cast of Fun Home and was a member of the Neo-Futurists alongside much of the Night Vale Presents crew, makes an uncredited voice cameo in the finale of Part 1.

[2] Cassandra Khaw of Ars Technica positively reviewed the first three episodes, stating that the series "very quickly comes into its own, dropping any pretence of gallows humour for the kind of creeping, consuming terror that pervades the best horror movies.

"[10] Neil Verma compared the modus operandi of the Thistle Man, the series' antagonist who follows its narrator as she drives across America, to that of the eponymous villain in Lucille Fletcher's 1941 radio play The Hitch-Hiker.