[4] Lowe began her career in surreal experimental theatre shows including City Haunts, Snowbound and Progress in Flying Machines[5] co-devising and performed along with colleagues such as Robert Webb and David Mitchell.

[6] Lowe worked under the directorship of Paul King,[7] who has since directed her in The Mighty Boosh and Garth Marenghi's Darkplace.

[7] She was cast in Garth Marenghi's Fright Knight[7] alongside fellow Cambridge graduates Richard Ayoade and Matt Holness and they were nominated for the Perrier Award at the Edinburgh Fringe in 2000.

[8] In 2001, she won an award for performing in the sequel to Fright Knight, Garth Marenghi's Netherhead,[7] at the Edinburgh Festival Fringe.

[4] Her television credits include Channel 4's spoof horror comedy Garth Marenghi's Darkplace,[7] Beth in the BBC comedy series My Life in Film, David Bowie in the BBC series Snuff Box,[7] and a recurring role in Rob Brydon's Annually Retentive.

[7] Lowe co-wrote and starred in the short film Stiffy, directed by Jacqueline Wright,[7] which premiered at Cannes in 2005 as part of the Kodak Straight 8 competition.