In 2003, she established the Association for the Defense of Homosexuality (ADEFHO), an organization that provides legal and social support to LGBTQ+ individuals in Cameroon, where same-sex relationships are criminalized.

[10] Nkom has represented numerous clients prosecuted under Section 347 bis of the Cameroonian Penal Code, which imposes penalties of up to five years in prison for same-sex relationships.

Nkom's most famous case was in 2005 when she defended a group of men who were arrested during a raid of a gay bar in the Cameroon capital city.

[15] In March 2020, Paul Atanga Nji, the Minister of Territorial Administration accused Redhac under Nkom's leadership of being engaged in a "conspiracy" against Cameroon and security services.

[6] On 10 December, Nkom was summoned to a police interview in Wouri after breaking the seal placed on the doors of Redhac's offices in Douala.