Having written 38 produced screenplays and directed 72 feature films, O'Fredericks was one of the most prolific directors in Danish cinema.
[2] The Alice Award, presented annually to the Best Female Director at the Copenhagen International Film Festival, is named in her honor.
[3] She was educated at a secretarial school then landed a job in 1918 as a script girl for Danish director, Benjamin Christensen.
Through the 1920s, she performed in several films including Gudmundur Kamban's drama Hadda Padda, and the comedy Pas Paa Pigerne for the popular Danish duo of Ole & Axel (Carl Schenstrøm and Harold Madsen).
Through Lauritzen's mentoring, O'Fredericks learned the craft of filmmaking which laid the groundwork for her long and successful career as a director.
In 1950, she took a solo turn in the director's chair at ASA Film with the filmatization of the Morten Korch novel De røde heste (The Red Horse).
In 2003, the Copenhagen International Film Festival created the Alice Award, named in her honor, to be given annually to the Best Female Director.