Born to a French father and a Chilean mother, Küppenheim spent her early years traveling around different parts of Europe due to her parents' trade, both of whom were artisans.

She later moved to TVN and appeared in the teleseries Trampas y caretas and Jaquemate, where she landed her first significant role as one of the young protagonists of the story alongside Felipe Camiroaga.

In film, Küppenheim starred in Sangre de Cuba (Dreaming of Julia), where she shared the screen with actors such as Gael García Bernal and Harvey Keitel.

In its opening week, the show climbed to the top of the streaming platform's list and settled into seventh place for the most successful non-English speaking series, accumulating 9.9 million hours viewed since its premiere.

After that, Küppenheim began a relationship with an Italian man named Renzo Melai, who died on June 23, 2008, after his motorcycle collided with a truck in Peñalolén, Chile.