[4] In her childhood years, Alisa Freindlich attended the drama and music classes of the Leningrad Palace of Pioneers.

In the 1950s, she studied acting at the Leningrad State Institute of Theatre, Music and Cinema, graduating in 1957 as actress.

[3] Although Freindlich put a premium on her stage career, she starred in several notable movies, including Eldar Ryazanov's enormously popular comedy Office Romance (1977), the long-banned epic Agony (1975) and Andrei Tarkovsky's[5] sci-fi movie Stalker (1979).

[6][7] On her 70th birthday, she was visited by Vladimir Putin in her Saint Petersburg apartment, who awarded her with the State Prize of the Russian Federation.

Yeaterina Tarkhanova, a columnist for film.ru, noted that Freindlich "performs the "old woman sketch" absolutely flawlessly: plastically, facially, intonation.

On 7 December 2009, on the stage of the Great Hall of the Central House of Actors named after Yablochkina, the Theatrical Star 2009 award ceremony was held.

[14] On 5 December 2014, in honor of Friendlich's 80-year anniversary, an exhibition dedicated to the history of her family, titled Theater Dynasties of Freindlich, was opened in St. Petersburg at the Museum-Apartment of Samoilov Actors, Stremyannaya, 8.