[6] She played "Tessie Tura" in the New York City Center and Broadway productions of Gypsy starring Patti LuPone under the direction of Arthur Laurents.

She was the first ever recipient of Philadelphia's Barrymore Award for Best Actress for her portrayal of "The Blonde" in Marion Adler, Scott Wentworth and Craig Boehmler's film noir musical, Gunmetal Blues under the direction of Jiri Zizka.

She played "Miss Drumgoole" in Todd Rundgren's adaptation of Joe Orton's Up Against It (New York Shakespeare Festival), "Uta" in Charles Busch and Rusty Magee's The Green Heart (Manhattan Theatre Club), "Connie"/"Petula"/"Brenda" in Beehive at the Village Gate, and "Marion Ames" in Swingtime Canteen.

She has appeared on the TV series Gotham, High Maintenance, Smash, Law and Order: Special Victims Unit, Happy!, and Third Watch.

She played the recurring roles of "Aunt Heidi" in the award-winning web-series Jack in a Box, written and produced by Michael Cyril Creighton, and "Veronica Bailey" on Wesley Taylor and Mitchell Jarvis’s It Could Be Worse (the latter web series was broadcast on Pivot and was later picked up by Hulu).

Her feature films include Socks and Bonds, Family Games, Blowtorch, Commentary, Jack and His Friends (with Sam Rockwell), Me and Him, Mixing Nia, In the Blood, The Mice War, Tommy Battles the Silver Sea Dragon, The Thing About My Folks, and Landscape with Invisible Hand.

She can also be seen in the Bright Eyes music video for their song, First Day of My Life, directed by her Secret Garden co-star, John Cameron Mitchell.

In 2010, playwright and performer Charles Busch cast Fraser in his new comedy, The Divine Sister, a play satirizes the cinematic portrayal of nuns.

From October 6 to November 22, 2015, Fraser performed in the world premiere of Michael John LaChiusa's musical First Daughter Suite at the Public Theater, in the roles of Nancy Reagan and Betty Ford.