[5][6][12] Noble started her career as a research scientist at the General Electric Corporate R&D Center in Schenectady, New York, where she worked from 1989 to 1994 on developing inspection systems for aircraft engines.

[1][16] Her research has advanced understanding of automatic extraction of clinically useful information from medical ultrasound scans and developed machine learning solutions to key problems in biomedical image analysis.

[17][18][19][20][21] Noble has supervised or co-supervised over 50 successful PhD students to completion[13][5] including Miklós Gyöngy,[22] Nathan Cahill,[23] Ramón Casero Cañas,[24] and Grace Vesom.

[2] Noble was promoted to Commander of the Order of the British Empire (CBE) in the 2023 Birthday Honours for services to engineering and biomedical imaging.

[32] In 2019, Professor Noble was awarded the Gabor Medal by the Royal Society "for developing solutions to a number of key problems in biomedical image analysis and substantially advancing automatic extraction of clinically useful information from medical ultrasound scans".