[1] Alison Skipworth made her first stage appearance at Daly's Theatre in London in 1894, in A Gaiety Girl.

After performing in two London plays, Skipworth returned to the United States, and made it her home.

Productions in which she was featured are The Torch-Bearers, The Swan, The Enchanted April, The Grand Duchess and the Waiter, Mrs. Dane's Defence and Marseilles.

Skipworth appeared opposite W. C. Fields as his foil in four films: If I Had a Million (1932), Tillie and Gus (1933), Alice in Wonderland (1933), and Six of a Kind (1934).

Her later screen credits include The Casino Murder Case, The Girl from 10th Avenue, King of the Newsboys, Wide Open Faces, and Ladies in Distress.