Martinez counts 1999 as her big break in comics when she was working as an assistant to Marvel editor Joe Quesada.

In recent years, she helped create the artwork, including cover art, for a special commemorative issue of Riverdale by Archie Comics.

[6] Martinez penciled most of the first five issues of World of Wakanda, a spin-off from the Marvel Comics' Black Panther title that was primarily written by Roxane Gay.

In 2019, Martinez released the series Omni with writer Devin K. Grayson for the Humanoids Publishing comic line.

[9] In 2020, art by Martinez was included in the exhibit Women in Comics: Looking Forward, Looking Back at the Society of Illustrators in New York City.