[1] Spiegel previously hosted and produced the NPR program Invisibilia with Lulu Miller and Hanna Rosin.
She was one of the early producers of This American Life, then went on to work for National Public Radio and The New York Times.
During her years on NPR's science desk Spiegel covered psychology and human behavior, with an emphasis on looking at how ideas about emotions come into existence and evolve.
[3] In 2008 she won the Robert F. Kennedy Journalism Award for her piece "Stuck and Suicidal in a Post-Katrina Trailer Park".
In 2022, after returning to This American Life, she was on the team that produced "The Pink House at the Center of the World", an episode about the overturn of Roe v Wade that won a Peabody.