[3] Each episode follows members of various Shia Muslim families going through the events of their daily lives, with emphasis placed on how their faith affects their actions.

Cast members also appear in short round table segments in which they discuss general principles of Islam as they relate to specific events depicted in the episode.

[8] Following a screening at the 2011 Television Critics Association Press Tour, The Hollywood Reporter dubbed All-American Muslim "fascinating".

Noting that the participants believed the series was not intended to be educational, THR nonetheless felt that "watching their lives will teach us a lot about the culture of Americans who practice Islam and how they're both similar and unique from us".

"[14] In response to Lowe's decision, celebrities including Russell Simmons and Mia Farrow called for a boycott of the retail outlet.

[15] Representative Keith Ellison, the first Muslim elected to the United States Congress, criticized Lowe's decision "to uphold the beliefs of a fringe hate group and not the creed of the 1st Amendment.

Michigan state representative Rashida Tlaib contacted the company's corporate headquarters, reporting that Lowe's declined to change its decision.

[17] California state senator Ted Lieu also issued a boycott call, labeling the Lowe's action "bigoted, shameful, and un-American".

[17] The Los Angeles chapter of the Council on American-Islamic Relations met to consider possible actions, including boycotts and protests.

[19] In response, Lowe's stated, "As you know, the TLC program 'All-American Muslim' has become a lightning rod for people to voice complaints from a variety of perspectives – political, social and otherwise.