The league runs a sixteen-game schedule and holds a championship game at the end of the playoffs, similar to the NFL.

[13][14] The gameplay of APF2K8 is considered better to the game play of Visual Concepts' previous title, ESPN NFL 2K5.

[9] In a court ruling, O. J. Simpson was ordered to pay the family of Ronald Goldman any money made for his appearance in the game.

[16] During pre-production of the game, Simpson was a member of the in-game team called the New Jersey Assassins.

Some pre-release videos showed Simpson performing these moves, implying to some that the designers were intentionally referencing the murders.