On September 26 that year, the then President Shankar Dayal Sharma laid the foundation stone of the Nurul Hasan Post-Graduate Institute of Medical Science and Research on the land.

[5][6] AIIMS Kalyani was set up as part of the Pradhan Mantri Swasthya Suraksha Yojana (PMSSY) initiative, announced by the Government of India in 2003 and officially launched in March 2006, for the purpose of "correcting regional imbalances in the availability of affordable/reliable tertiary healthcare services", through setting up AIIMS Delhi-like institutions and upgrading government medical colleges.

[7][8] In Feb 2009 Union cabinet approved the proposal to set-up AIIMS like institution in West Bengal.

[10] The AIIMS was officially announced in July 2014,[11] in the budget speech for 2014–15,[12] where the Minister of Finance Arun Jaitley announced a budget of ₹500 crore (equivalent to ₹799 crore or US$92 million in 2023) for setting up the four "Phase-IV" AIIMSs, in Andhra Pradesh, West Bengal, the Vidarbha region of Maharashtra and the Purvanchal region in Uttar Pradesh.

[11] In March 2015, the union cabinet gave an official approval for the location, on a 150-acre lot in the village Basantapur, near Kalyani.

[1]The mentoring institution was AIIMS Bhubaneswar,[17] the first director appointed was Dipika Deka[18] and Chitra Sarkar selected as president.

[24] On 1 March 2022, first Academic season of B.Sc (Nursing) course with 60 number of seats capacity inaugurated by institute president.

[25] In November 2022, Institute has been permitted to run postgraduate courses with 26 number of seats allocated for INI-CET January 2023 session.

[27] The seal of the institution highlights various famous structures, agricultural crops, places and rivers of Bengal.

Above and below the seal, the name of the institution is written in Sanskrit and English respectively, and a total of two rice sheafs are depicted on each side.

The book represents the portrait of Kalyani AIIMS as an institution providing education to medical students.

The roots-like part beneath the bars of Asclepius represents the mangrove forests of the Sundarbans formed by the Gangetic Delta, Brahmaputra, Meghna River which houses many Flora and fauna recognized by UNESCO World Heritage Site.The Bengal tiger symbolizes the pride of Bengal also the national animal of our country.

Also, the Service area is roughly located near the boundary wall at the western end of the campus, such as electrical substations.

There are 5 residential buildings for staff, one guest house and an executive director's residence in the northern part of the campus.

[33][34] For MBBS courses, admission is based on the National Eligibility cum Entrance Test (NEET–UG) rankings.

The institute runs a Short Term Studentship (STS) scheme under Indian Council of Medical Research (ICMR).

[38] signed a MoU for development of a collaborative platform for academic and research promotion and potential faculty and students exchange program in near future with NIBMG, IIIT Kalyani in September 2021.

[39] In July 2023 signed an agreement with IIT Kharagpur for collaboration in education, research and medical services.

[43] On 2024 Authorities of the institution written requested to Government of West Bengal to let it become a service provided for the Swasthya Sathi scheme.

[44] On May 20, 2022, a CID West Bengal lodged a FIR at Nadia Police Station based on a complaint filed by one Sariful Islam from Murshidabad.

[45] Four BJP MLA, MP including Union Minister of State for Education Subhas Sarkar have been named in FIR, accusing them of using their influence to get jobs for their relatives at AIIMS, Kalyani.

[46] "The Calcutta High Court has directed the Government of India to revamp the infrastructure of AIIMS Kalyani so that it can be brought at par with AIIMS Delhi" Justice Tirthankar Ghosh made the remarks while hearing a petition seeking an autopsy of a minor girl who was raped and murdered in Joynagar area of West Bengal.