It is known for its association with Lewis Carroll who is commemorated in its stained glass windows depicting characters from Alice's Adventures in Wonderland.

[2] The author Lewis Carroll was born in All Saints' Vicarage in 1832 when his father, Charles Dodgson, was perpetual curate at the church.

[4] In the 12th century a chapelry was founded on the site of the present church as a daughter house of Norton Priory.

Over the years there were frequent disputes between the worshippers at Daresbury and the mother church at Runcorn relating to financial matters.

They lengthened the church, extended the clerestory to the east, and added a new north porch and vestry, for £6,000 (equivalent to £680,000 in 2023).

[11] Families who have been associated with the church over the centuries are those of Greenall, Rylands, Chadwick, Heron, Milner, Houghton, and Okell.

[1] The pulpit is Jacobean with carvings of heads of angels which Richards considers to be possibly the most elaborate of their kind in the county.

[14] The stained glass in the windows of the south aisle depicts the eleven apostles without Judas Iscariot.

The windows incorporate symbolic panels relating to Carroll's life, including the Cheshire wheatsheaf, the arms of Rugby School and Christ Church, Oxford, and mathematical instruments.

Across the base of the window are five panels which include characters from the Alice books together with words from Carroll's poem Christmas Greetings.

On the south wall are windows designed by Trena Cox depicting The Flight into Egypt and The Annunciation which were donated to the church in 1960 in memory of the Broome family of Preston-on-the-Hill.

On the walls are descriptive panels giving information about Charles Dodgson, Lewis Carroll, and other members of the family.