The working title of the song was "Jimmy Webb on Mars," which, according to Buck's notes, was a "sick tribute to a songwriter who we all admire.

"[4] The song's video was shot at Bishop Ford Central Catholic High School in the Prospect Park area of Brooklyn, New York.

In the video, Buck and Mike Mills can be seen entering the Career Guidance office with their respective instruments in hand, only to leave armed with nothing more than a dustpan and brush.

Bertis Downs makes an appearance as the school's announcer, only to have his microphone commandeered by Michael Stipe.

"Imitation of Life" was recorded live at Trafalgar Square (London, England) on April 29, 2001.