The Lindsey C. Warren Bridge of U.S. Route 64 crosses the river.

Habitat bordering the Refuge includes many diverse types including high and low pocosin,[7] bogs, fresh and brackish water marshes, hardwood swamps, and Atlantic white cypress swamps.

Plant species include pitcher plants and sun dews, low bush cranberries, redbay, Atlantic white cypress, pond pine, American sweetgum, red maple, and a wide variety of herbaceous and shrub species common to the East Coast.

The refuge is one of the premier strongholds for American black bear[8] on the Eastern Seaboard.

The wildlife diversity includes wading birds, shorebirds, American woodcock, raptors, black bears, alligators, white-tailed deer, raccoons, cottontail rabbits, bobwhite quail, northern river otters, red wolves,[9][10] red-cockaded woodpeckers,[11] and neotropical migrants.