DuBois claims she used her psychic abilities to assist U.S. law enforcement officials in solving crimes, forming the basis of the TV series Medium.

[1] According to TV Guide, DuBois spent four years participating in various tests at the University of Arizona to assist with their studies of mediums and psychic phenomena.

Gary Schwartz, director of the VERITAS research project, claims that DuBois has psychic abilities, arguing in the March 6, 2005, TV Guide, "Anyone who's looked closely at the evidence can't help but come to the conclusion that there is something very real going on here."

[6] The television drama Medium, which aired from 2005 until 2011 on NBC and CBS[7] is based on DuBois's book, Don't Kiss Them Good-Bye.

DuBois stated in the January 9, 2005, TV Guide that she initially thought Arquette was too liberal to play her, remarking, "I mean, I have a gun, I have put people on death row.

[3] She does state in both her book and in the January 3, 2005, edition of Sci Fi Weekly that the program closely resembles the truth of her own life.

[4] Several details of Arquette's character match DuBois's life, such as the name of her husband on the show (Joe) and the fact that he is an aerospace engineer.

[5] Skeptic James Randi says that people such as DuBois give the appearance of psychic powers through cold reading techniques.

Randi also asserts that experiments that allegedly yield positive results of psychic powers, such as the ones done with DuBois, are not conducted using proper scientific controls.

[12] In 2011, the JREF again issued the million dollar challenge to James Van Praagh, DuBois, Sylvia Browne, Carla Baron, John Edward, and others to prove their abilities in controlled experiments, commenting, "James Van Praagh and Allison DuBois have turned the huckster art of 'cold reading' into a multi-million-dollar industry, preying on families' deepest fears and regrets", he said in a statement announcing the challenge.