The Almelo–Salzbergen railway is a both Dutch and German 54 kilometre long railway line, that connects Almelo with Salzbergen, offering a rail link between the Netherlands and Germany.

In Salzbergen the line connected with the Emsland Railway, which had opened in 1855.

The railway connects Almelo in a south easterly direction with Hengelo.

At Bad Bentheim the private freight railway to Nordhorn and Coevorden branches out, heading north.

The Almelo–Salzbergen railway is used by the following passenger services: A wide variety of trains can be found regularly on the Almelo–Salzbergen railway: There are also large number of freight trains operating along the line.