After waking up from a 17-month coma, Kennex has to deal with a cybernetic prosthetic leg and huge gaps in his memory, which he tries to recover through visits to a black market memory-recovery doctor called a Recollectionist, in the city slums.

Kennex is then recalled to the force by Captain Sandra Maldonado (Lili Taylor), and partnered with a standard-issue MX-43 android, which he soon throws from a moving vehicle, when it threatens to report his unusual behavior.

He is assigned a replacement android, an older DRN model originally decommissioned for police work and about to be transferred to the Space Station.

[1] Created to be as close to human as possible, the DRN androids have trouble dealing with some of their own emotional responses, which was the reason they were replaced by the logic-based MX units.

[2] Kennex's unit, known as Dorian (Michael Ealy), immediately proves himself unique, with a clear dislike of being referred to as a "synthetic", and a dry, friendly, sarcasm-oriented wit.

The website's consensus reads: "Almost Human presents enough action and humor to please both young watchers and fans of the sci-fi genre, but mainstream audiences may find it bland.

Club gave the pilot episode a C+ grade, criticizing the information-heavy introduction and title card, but noting "flashes of excitement" and expressing interest in how the plot gets teased out and how the detective partnership develops.