[9][10] Mayo co-directed the Southern Poverty Law Center's Teaching Tolerance documentary Viva La Causa, about the life of Cesar Chavez,[11][12][13] which was shortlisted for the 2008 Academy Awards.

[14] In 2010, Mayo directed the dramatic web series Untitled Fiction Project about the aftermath of an affair.

[15] The storyline was later continued in 2013's Untitled Murder Project 2.0, a 36 episode experiment in nonlinear storytelling.

[16][17] Mayo directed his first feature film in 2011, the comedy-drama The Story of Luke about a young man with autism on a quest for a job and a girlfriend, starring Lou Taylor Pucci, Seth Green, Cary Elwes and Kristin Bauer.

[18][19][20] The film was inspired by Mayo's experiences with young men and women on the autism spectrum at Centro Ann Sullivan del Perú as seen in his research documentary Just Like Anyone.